SOFTWARE DOWNLOAD
Instructions:
1 - Download and install .net framework
2.0 from here
2 - Download and install Prober 2.00 + human
mer database using the windows msi installer
PROBER 2.0 windows installers are available by FTP access:
ROMAFILES.CSHL.EDU
login : prober
pass : proberpass
you may connect to this ftp site from here
New Version Released (V2.1):
PROBER 2.1-F5.2004
(1.2 gb total download)
Updates:
• Wallace method has been replaced with Rychlik et al. implementation for primer Tm calculations
• GC Clamp implementation optimizes avoidance of GC dimers
Note: This version has NOT been tested experimentally.
**Experimental validation of probe PCR reactions and TOP-FISH hybridization are currently being conducted
Current PROBER Versions :
PROBER 2.0-F5.2004
This version contains PROBER + the UCSC human genome 5.2004 mer database
(1.2 gb total download)
PROBER 2.0-F4.2003
This version contains PROBER + the UCSC human genome 4.2003 mer database
(1.2 gb total download)
Note: These versions have been experimentally validated.
INSTALLATION INSTRUCTIONS:
Download the *.zip file and extract it to temporary directory.
Please Note ! You must unzip with full directory expansion enabled from the zip file.
In winzip please be sure to select the 'Use Folder Names' checkbox when unzipping.
Run Prober_Installer.exe from that directory and install to C:\PROBER
Previous Versions :
• PROBER 1.40-F5.2004
• PROBER 1.40-F4.2003
• PROBER 1.20-F4.2003
• PROBER 1.0
minimum requirements:
PC machine with Windows 2000, NT or XP with at least 516mb of RAM and a 866mhz pentium 3 processor
recommended configuration:
PC machine with Windows 2000, NT or XP with 1gb of RAM and a pentium 4 processor
