name is Nicholas Navin and I am a programmer / Ph.D. student in Mike Wigler's
lab at the Cold Spring Harbor Laboratory.
PROBER was written in Mike Wigler's lab at the Cold
Spring Harbor Laboratory. This software was orginally designed to
determine the copy number of amplifications and deletions that occur in
cancer cells. However, many other laboratries are now using PROBER
to determine genomic copy number in autism and other genetic
diseases as well as copy number variation that occurs in the 'normal'
Over the last years, with a lot of help from other members in the Wigler
lab (Jim Hicks, Evan Leibu, Mike Wigler), we have improved the algorithms
and identified the optimal parameters needed to design highly specific
We also work very closely with our collaborators in Sweden - the Zetterberg
lab, who have helped us determine the optimal parameters and experimental
conditions required to improve the specificity and signal of Oligo FISH
probes. Our lab and many other research laboratories are currently using
PROBER to study copy number variation and abberrations for many
applications in molecular biology.