ABOUT

My name is Nicholas Navin and I am a programmer / Ph.D. student in Mike Wigler's lab at the Cold Spring Harbor Laboratory.

PROBER was written in Mike Wigler's lab at the Cold Spring Harbor Laboratory. This software was orginally designed to determine the copy number of amplifications and deletions that occur in cancer cells.  However, many other laboratries are now using PROBER to determine genomic copy number in autism and other gen
etic diseases as well as copy number variation that occurs in the 'normal' human population.

Over the last years, with a lot of help from other members in the Wigler lab (Jim Hicks, Evan Leibu, Mike Wigler), we have improved the algorithms and identified the optimal parameters needed to design highly specific DNA probes.

We also work very closely with our collaborators in Sweden - the Zetterberg lab, who have helped us determine the optimal parameters and experimental conditions required to improve the specificity and signal of Oligo FISH probes. Our lab and many other research laboratories are currently using PROBER to study copy number variation and abberrations for many applications in molecular biology.

Home
Introduction
Tutorial
Simulations
Applications
Download
Links
about
contact
publications
people